English Version>>




作者:    发布时间:2013-05-06    点击率:1




Email: chenak@pku.edu.cn                                                                                                        




  • 1996-2000    学士加州大学-圣地亚哥校区 (UC San Diego)                                   专业:生物医学工程


  • 2000-2002    硕士加州大学-圣地亚哥校区   (UC San Diego)                   专业:生物医学工程


  • 2004-2008    博士宾夕法尼亚大学 (University of Pennsylvania)             专业:生物医学工程




活细胞分子成像,RNA纳米探针RNA-蛋白交互作用非编码RNA (microRNA/Long ncRNA) 新功能研究,病毒与宿主细胞交互作用纳米医学等




  • 青年千人 2012
  • National Research Council (NRC) Research Associate Fellowship (2010-2012).
  • Solomon R. Pollack Award for Excellence in Graduate Bioengineering Research (2009)
  • UPENN Graduate Student Fellowship (2004-2008)
  • Best Consulting Team Award (2008)
  • Semi-Finalist, The Wharton Business Plan Competition (2007)
  • Outstanding Poster Presentation Award, Optical Imaging Retreat (2007)
  • Joint Molecular Imaging Conference Student Travel Award (2007)
  • Society of Molecular Imaging Student Travel Award (2006)
  • UCLA Graduate Student Fellowship (2002-2003)
  • UCSD Cum Laude (June 2000)
  • UCSD Undergraduate Outstanding Research Award (Spring 2000) 
  • UCSD Provost Honors, Spring 97, Fall 97, Winter 98, Spring 98, Winter 99, Spring 99






1. Chen, A.K. Sengupta, P., Waki, K., Schuyler, V.E., Ablan, S.D., Freed E.O. and Lippincott-Schwartz J*. Binding of microRNA to the HIV-1 Gag protein inhibits virus production by disrupting Gag assembly at the plasma membrane. Manuscript in preparation.


2. Chen, A.K.* Delrio, F., Peterson, A.W., Chung, K.H., Bhadriraju, K, and Plant, A.L. Cell spreading and proliferation in response to the composition and mechanics of engineered fibrillar extracellular matrices. *Corresponding Author. Biotechnol Bioeng. Accepted.

3. Chen, A.K.* and Tsourkas A. Developing Molecular-Beacon Constructs for Improved Live-Cell Analysis and Imaging of RNA. *Corresponding Author. Am. Biotech. Lab. 2010; 28 (7): 10-13. (Review)

4. Chen, A.K., Davydenko, O., Behlke, M., and Tsourkas A.* Ratiometric Bi-Molecular Beacons: Ratiometric Bimolecular Beacons for the Sensitive Detection of RNA in Single Living Cells. Nucleic Acids Res. 2010; 38 (14): e148.

5. Cheng, Z., Chen, A.K., Lee H-Y., and Tsourkas, A.* Examination of Folate-Targeted Liposomes with Encapsulated Poly(2-Propylacrylic acid) as a pH-responsive Nanoplatform for Cytosolic Drug Delivery. Small. 2010; 6 (13): 1398-401.

6. Chen, A.K., Behlke, M., and Tsourkas, A.* Subcellular Trafficking and Functionality of 2'-O-methyl and 2'-O-methy-phosphorothioate Molecular Beacons. Nucleic Acids Res. 2009; 37 (22): e149.

7. Chen, A.K. and Tsourkas, A.* Imaging RNA in Living Cells with Molecular Beacons: Current Perspectives and Challenges. J. Innov. Opt. Health Sc. 2009; 2 (4): 315-324. (Review) 

8. Chen, A.K., Cheng, Z., Behlke, M., and Tsourkas, A.* “Assessing the Sensitivity of Commercially Available Fluorophores to the Intracellular Environment”. Anal Chem. 2008; 80 (19): 7437-44.

9. Chen, A.K., Behlke, M., and Tsourkas, A.* “Efficient Cytosolic Delivery of Molecular Beacon Conjugates and Flow Cytometric Analysis of Target RNA”. Nucleic Acids Res. 2008; 36 (12): e69.             

10. Elias, D.R., Thorek, D.L., Chen, A.K., Czupryna, J., and Tsourkas, A.* “In vivo Imaging of Cancer Biomarkers Using Activatable Molecular Probes”. Cancer Biomarkers. 2008; 4 (6): 287-305. (Review).

11. Chen, A.K., Behlke, M., and Tsourkas, A.* “Avoiding False-Positive Signals with Nuclease-Vulnerable Molecular Beacons in Single Living Cells”. Nucleic Acids Res. 2007; 35 (16): e105.

12. Chen, A.K., Latz, M.I., Sobolewski, P., and Frangos, J.A.* “Evidence for the Role of G-Proteins in Flow Stimulation of Dinoflagellate Bioluminescence.” Am J Physiol Regul Integr Comp Physiol. 2007; 292(5): R2020-7.

13. Thorek, D.L.J., Chen, A.K., Czupryna, J., and Tsourkas, A.* “Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging.” Ann Biomed Eng. 2006; Jan;34(1):23-38 (Review).

14. Chen, A.K., Latz, M.I., and Frangos, J.A.* The Use of Dinoflagellate Bioluminescence to Characterize Cell Stimulation in Bioreactors.” Biotechnol Bioeng. 2003; 83(1): 93-103.





1. Chen, A.K., Rhee, W.J., Bao G. and Tsourkas A.* (2010) Delivery of Molecular Beacons for Live-cell Imaging and Analysis of RNA. In Methods in Molecular Biology: Messages on the move: Techniques in RNA visualization, edited by Gerst, J.E., The Humana Press Inc.

2. Crayton, S.H., Chen, A.K., Cheng, Z., Tsourkas, A.* (2010) Molecular Imaging In Comprehensive Biomaterials, edited by Ducheyne, P., Healy, K., Hutmacher, D., Kirkpatrick, J., Elsevier Inc.  In press.

3. Thorek, D.L.J., Czupryna, J., Chen, A.K., Tsourkas, A.* (2006) Molecular Imaging of Cancer with Superparamagnetic Iron Oxide Nanoparticles. In Cancer Imaging, edited by M.A. Hayat. Elsevier Science/Academic Press.



1. Andrew Tsourkas and Antony Chen. Quantitative Molecular Probes, 2007. US Application Number: 12/282.612; International Application Number: PCT/US07/064099.

2. Andrew Tsourkas and Antony Chen. Novel Molecular Beacons. 2009. US application  Number:61/244,378;  International Application Number: PCT/US10/49301




招聘本科生, 研究生, 科研助理以及博士后。具有RNA生化,生物物理, 细胞荧光成像, 分子生物学或工程学背景。有意应聘者请将个人简历和工作背景简介发送到个人邮箱

Email: chenak@pku.edu.cn