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教职员工

陈匡时

作者:    发布时间:2013-05-06    点击率:1

陈匡时博士

特聘研究员

北京市海淀区颐和园路5。邮编100871

Email: chenak@pku.edu.cn                                                                                                        

 

教育

 

  • 1996-2000    学士加州大学-圣地亚哥校区 (UC San Diego)                                   专业:生物医学工程

 

  • 2000-2002    硕士加州大学-圣地亚哥校区   (UC San Diego)                   专业:生物医学工程

 

  • 2004-2008    博士宾夕法尼亚大学 (University of Pennsylvania)             专业:生物医学工程

 

主要研究方向

 

活细胞分子成像,RNA纳米探针RNA-蛋白交互作用非编码RNA (microRNA/Long ncRNA) 新功能研究,病毒与宿主细胞交互作用纳米医学等

 

获得奖项

 

  • 青年千人 2012
  • National Research Council (NRC) Research Associate Fellowship (2010-2012).
  • Solomon R. Pollack Award for Excellence in Graduate Bioengineering Research (2009)
  • UPENN Graduate Student Fellowship (2004-2008)
  • Best Consulting Team Award (2008)
  • Semi-Finalist, The Wharton Business Plan Competition (2007)
  • Outstanding Poster Presentation Award, Optical Imaging Retreat (2007)
  • Joint Molecular Imaging Conference Student Travel Award (2007)
  • Society of Molecular Imaging Student Travel Award (2006)
  • UCLA Graduate Student Fellowship (2002-2003)
  • UCSD Cum Laude (June 2000)
  • UCSD Undergraduate Outstanding Research Award (Spring 2000) 
  • UCSD Provost Honors, Spring 97, Fall 97, Winter 98, Spring 98, Winter 99, Spring 99

 

 

 

文章及专利

 

1. Chen, A.K. Sengupta, P., Waki, K., Schuyler, V.E., Ablan, S.D., Freed E.O. and Lippincott-Schwartz J*. Binding of microRNA to the HIV-1 Gag protein inhibits virus production by disrupting Gag assembly at the plasma membrane. Manuscript in preparation.

 

2. Chen, A.K.* Delrio, F., Peterson, A.W., Chung, K.H., Bhadriraju, K, and Plant, A.L. Cell spreading and proliferation in response to the composition and mechanics of engineered fibrillar extracellular matrices. *Corresponding Author. Biotechnol Bioeng. Accepted.

3. Chen, A.K.* and Tsourkas A. Developing Molecular-Beacon Constructs for Improved Live-Cell Analysis and Imaging of RNA. *Corresponding Author. Am. Biotech. Lab. 2010; 28 (7): 10-13. (Review)

4. Chen, A.K., Davydenko, O., Behlke, M., and Tsourkas A.* Ratiometric Bi-Molecular Beacons: Ratiometric Bimolecular Beacons for the Sensitive Detection of RNA in Single Living Cells. Nucleic Acids Res. 2010; 38 (14): e148.

5. Cheng, Z., Chen, A.K., Lee H-Y., and Tsourkas, A.* Examination of Folate-Targeted Liposomes with Encapsulated Poly(2-Propylacrylic acid) as a pH-responsive Nanoplatform for Cytosolic Drug Delivery. Small. 2010; 6 (13): 1398-401.

6. Chen, A.K., Behlke, M., and Tsourkas, A.* Subcellular Trafficking and Functionality of 2'-O-methyl and 2'-O-methy-phosphorothioate Molecular Beacons. Nucleic Acids Res. 2009; 37 (22): e149.

7. Chen, A.K. and Tsourkas, A.* Imaging RNA in Living Cells with Molecular Beacons: Current Perspectives and Challenges. J. Innov. Opt. Health Sc. 2009; 2 (4): 315-324. (Review) 

8. Chen, A.K., Cheng, Z., Behlke, M., and Tsourkas, A.* “Assessing the Sensitivity of Commercially Available Fluorophores to the Intracellular Environment”. Anal Chem. 2008; 80 (19): 7437-44.

9. Chen, A.K., Behlke, M., and Tsourkas, A.* “Efficient Cytosolic Delivery of Molecular Beacon Conjugates and Flow Cytometric Analysis of Target RNA”. Nucleic Acids Res. 2008; 36 (12): e69.             

10. Elias, D.R., Thorek, D.L., Chen, A.K., Czupryna, J., and Tsourkas, A.* “In vivo Imaging of Cancer Biomarkers Using Activatable Molecular Probes”. Cancer Biomarkers. 2008; 4 (6): 287-305. (Review).

11. Chen, A.K., Behlke, M., and Tsourkas, A.* “Avoiding False-Positive Signals with Nuclease-Vulnerable Molecular Beacons in Single Living Cells”. Nucleic Acids Res. 2007; 35 (16): e105.

12. Chen, A.K., Latz, M.I., Sobolewski, P., and Frangos, J.A.* “Evidence for the Role of G-Proteins in Flow Stimulation of Dinoflagellate Bioluminescence.” Am J Physiol Regul Integr Comp Physiol. 2007; 292(5): R2020-7.

13. Thorek, D.L.J., Chen, A.K., Czupryna, J., and Tsourkas, A.* “Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging.” Ann Biomed Eng. 2006; Jan;34(1):23-38 (Review).

14. Chen, A.K., Latz, M.I., and Frangos, J.A.* The Use of Dinoflagellate Bioluminescence to Characterize Cell Stimulation in Bioreactors.” Biotechnol Bioeng. 2003; 83(1): 93-103.

 

 

出版书籍

 

1. Chen, A.K., Rhee, W.J., Bao G. and Tsourkas A.* (2010) Delivery of Molecular Beacons for Live-cell Imaging and Analysis of RNA. In Methods in Molecular Biology: Messages on the move: Techniques in RNA visualization, edited by Gerst, J.E., The Humana Press Inc.

2. Crayton, S.H., Chen, A.K., Cheng, Z., Tsourkas, A.* (2010) Molecular Imaging In Comprehensive Biomaterials, edited by Ducheyne, P., Healy, K., Hutmacher, D., Kirkpatrick, J., Elsevier Inc.  In press.

3. Thorek, D.L.J., Czupryna, J., Chen, A.K., Tsourkas, A.* (2006) Molecular Imaging of Cancer with Superparamagnetic Iron Oxide Nanoparticles. In Cancer Imaging, edited by M.A. Hayat. Elsevier Science/Academic Press.

 

专利

1. Andrew Tsourkas and Antony Chen. Quantitative Molecular Probes, 2007. US Application Number: 12/282.612; International Application Number: PCT/US07/064099.

2. Andrew Tsourkas and Antony Chen. Novel Molecular Beacons. 2009. US application  Number:61/244,378;  International Application Number: PCT/US10/49301

 

 

职位信息

招聘本科生, 研究生, 科研助理以及博士后。具有RNA生化,生物物理, 细胞荧光成像, 分子生物学或工程学背景。有意应聘者请将个人简历和工作背景简介发送到个人邮箱

Email: chenak@pku.edu.cn

 

来信主题请注明职位。