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教职员工

葛子钢

作者:    发布时间:2010-05-20    点击率:1

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担任职务:
 
北京大学工学院生物医学工程系特聘研究员
北京大学先进前沿交叉研究院生物材料与组织工程中心研究员
北京大学人民医院伦理委员会委员

教育经历:
1993年 北京医科大学(现北京大学医学部),医学学士
2001年 新加坡国立大学(National U of Singapore),理学硕士
2005年 新加坡国立大学(National U of Singapore),医学博士

联系方式:
办公地点:北京大学廖凯原楼2-303
电话:6275 6736
Email: gez (at) pku.edu.cn
个人主页:http://www.coe.pku.edu.cn/subpaget.asp?id=16


研究领域:
骨,软骨和韧带再生医学
胚胎干细胞和骨髓基质干细胞
骨关节炎发病机制和治疗
生物材料

工作经历:
骨科医生,        北京积水潭医院骨科,            1993-1999
博士后研究员,     新加坡国立大学干细胞实验室,     2005-2006
新加坡千禧年学者,新加坡国立大学干细胞实验室,     2006-2007
特聘研究员,       北京大学工学院生物医学工程系,   2007-

获得荣誉:
1999年卫生部公派赴日临床研修世川奖学金
2006年新加坡千僖年学者 (Singapore Millennium Scholar)
研究方向:

1. 关节炎与软骨再生(Arthritis & Cartilage Regeneration)
2. 干细胞(Embryonic stem cell)
3. 功能性生物材料(Functional Biomaterials)
4. 生物医学实验技术 (Biomedical Techniques)

课题组成员:

博士后:
唐晓艳:再生生物学

博士研究生:
李超:功能性生物材料
张堃:软骨成像,骨关节炎动物模型
张晶晶:生物材料
黎一江:再生生物学

硕士研究生:
汪丽丽:再生生物学
窦亚娜:生物材料

本科生:
韩倩倩:再生生物学

实验员:
马娟娟 jius33sohu.com

以前组员:
张 映 博士后:干细胞分化基因调控   2010年7月出站 中国科学院动物所
尹 晶 硕士研究生:软骨细胞治疗。  2010年7月  国家发改委产业研究所
方喻晓 实验助理:体外模型    2010年4月
王静雯:硕士研究生,2008年毕业。

 

招生招聘信息:

北京大学工学院生物医学工程系再生医学和生物学实验室招聘博士后
招聘条件:
1.      具有生物学,生物化学,或基础医学背景博士学位(或即将毕业),有志从事科学研究;
2.      良好的分子/细胞生物学相关背景;
3.      在SCI杂志上发表过相关专业论文优先考虑;
4.      有软骨和干细胞实验经验优先考虑。
5.      有独立工作能力,责任心和团队精神;
6.      乐于学习,工作踏实,思想开放,作风正派。
7.      符合北京大学博士后的招收条件
(请参考如下网页:http://www.postdoctor.org.cn)
 
科研方向:软骨再生,胚胎干细胞

应聘材料:
1.中英文简历和申请信;
2.论文论著以及专利目录,3篇代表作全文;
3.三位推荐人的联系方式。
联系人: 葛子钢
请发简历至:gez(at)pku.edu.cn
电话: (010)62756736
实验室详情请参阅:http://www.coe.pku.edu.cn/subpaget.asp?id=16
 
实验员招聘

一.  应聘条件:

a)        具有生物学,生物化学,或基础医学硕士以上学位(或即将毕业)
b)        有第一作者SCI文章发表
c)        热爱实验室科研,有团队工作经验。 
二.岗位:
科研管理,团队科研/独立科研。 
三.待遇:竞争性薪酬,具体面议。
四.应聘材料:
文章原文
个人简历

申请者请先递交应聘材料电子文本至
葛子钢gez(at)pku.edu.cn
2010年12月发布


文章发表:

 

16. Zheng Yang*, Yingnan Wu, Chao Li, James Hui, Zigang GE*, Eng Hin Lee. Improved mesenchymal stem cells attachment and in vitro
cartilage tissue formation on chitosan-modified poly(Llactide-
co-epsilon-caprolactone) scaffold. Tissue Engineering, Part A (In press).
 
15.Jing Yin,Zheng Yang,Yongping Cao*,Zigang Ge*. Characterization of Human Primary Chondrocytes
 of Osteoarthritic Cartilage at Varying Severity. Chinese Medical Journal (In Press).
 
14. Chao Li, Lili Wang, Zheng Yang*, Gonhyung Kim, Haifeng Chen, Zigang Ge*.
A Viscoelastic Chitosan-modified three-dimensional Porous Poly (L-lactide-co-ε-caprolactone)
Scaffold for Cartilage Tissue Engineering. Journal of Biomaterials Science: Polymer Edition (In Press).
 
13. Hailong Fan, Lili Wang, Keke Zhao, Nan Li, Zujin Shi, Zigang Ge and Zhaoxia Jin. 
Fabrication, Mechanical Properties, and Biocompatibility of Graphene-Reinforced Chitosan 
Composites. Biomacromolecules (2010).  
 
12. Qichao Zhao, Jing Yin, Xunda Feng, Zujin Shi, Zigang Ge* and Zhaoxia Jin*. A biocompatible chitosan composite containing phosphotungstic acid modified single-walled carbon nanotubes. Journal of Nanoscience and Nanotechnology, 10:1-4(2010).
 
11.李超,曹永平,关振鹏,黄德勇,葛子钢*。蛋白聚糖酶和骨关节炎。北京大学学报(医学版), 41(5):611-613(2009).
 
10. Zigang, GE,Xianfeng TIAN, Boon Chin HENG, Victor FAN, Jin Fei YEO, Tong CAO. Histological Evaluation of osteogenesis of 3D-Printed Poly-Lactic-co-glycolic Acid (PLGA) Scaffolds in Rabbit Model. Biomedical Materials, 4(2):1-7(2009). 
 
9. Zigang Ge, Lishan Wang, Boon Chin Heng, Eunice Phay-Shin Tan, Xian Feng Tian, Kai Lu, Victor Tai-Weng Fan, Jin Fei Yeo, Tong Cao. Proliferation and Differentiation of Human Osteoblasts within 3D printed Poly-Lactic-co-Glycolic Acid (PLGA)  Scaffolds, Journal of Biomaterials Applications, 23:533-547 (2009). 
 
8. Zigang Ge, Zhaoxia Jin, Tong Cao. Manufacture of degradable polymeric scaffolds for bone regeneration. Biomedical Materials,  3(2):1-11 (2008).
 
7. Zigang Ge, Yang Hu, Boon Chin Heng, Zheng Yang, Hongwei Ouyang, Eng Hin Lee, Tong Cao. Osteoarthritis and Therapy.   Arthritis Care & Research, 55 (3): 493-500 (2006).
 
6. Zigang Ge, Fang Yang, James CH Goh, Seeram Ramakrishna, Eng Hin Lee. Biomaterials and Scaffolds for Ligament Tissue Engineering. Journal of Biomedical Material Research, 77A:639-652 (2006). 
 
5. Zigang Ge, James CH Goh, Eng Hin Lee. The Effects of Bone Marrow-derived Mesenchymal Stem Cells and Fascia Wrap Application to Anterior Cruciate Ligament Tissue Engineering. Cell Transplantation, 14(10):763-773 (2005).
 
4. Zigang Ge, Lishan Wang, Eunice PS Tan, James CH Goh, Eng Hin Lee. Characterization of knitted polymeric scaffolds for potential use in ligament tissue engineering. Journal of Biomaterials Science-polymer edition, 16(9):1179-1192 (2005).
 
3. Zigang Ge, James CH Goh, Eng Hin Lee. Selection of cell sources for ligament tissue engineering. Cell Transplantation,  14(8):573-583 (2005).
 
2. Zigang Ge, Sophie Baguenard, Lee Yong Lim, Aileen Wee, Eugene Khor. Hydroxyapatite-chitin materials as potential issueengineered bone substitutes. Biomaterials, 25(6):1049-1058 (2004).
 
1.葛子钢,范源,王承武。儿童肱骨髁上骨折神经损伤。中华小儿外科,17(5):291-2 (1996)。
 
合作研究:
11. Boon Chin Heng, Mark Richards, Zigang Ge3 and Yimin Shu. Induced adult stem (iAS) cells and induced transit amplifying progenitor (iTAP) cells – a possiblealternative to induced pluripotent stem (iPS) cells? J Tissue Eng Regen Med 2009.
 
10. Y.Y. Cai, C.W. Yap, Z. Wang, P.C. Ho, S.Y. Chan, K.Y. Ng, Z.G. Ge and H.S. Lin. Solubilization of vorinostat by cyclodextrins.Journal of Clinical Pharmacy and Therapeutics, 34: 1–6 (2009).
 
9. Tian, X-F; Heng, B-C; Ge, Z; Lu, K; Rufaihah, A J; Fan, V T-W; Yeo, J-F; Cao, T. Comparison of osteogenesis of human embryonic stem cells within 2D and 3D culture systems. Scandavia Journal of Clinical & Lab Investigation, 68(1):58-67(2008).
 
8. Heng, Boon Chin; Ye, Chao Peng; Liu, Hua; Toh, Wei Seong; Rufaihah, Abdul Jalil; Yang, Zheng; Bay, Boon Huat; Ge, Zigang; Ouyang, Hong Wei; Lee, Eng Hin; Cao, Tong. Loss of viability during freeze-thaw of intact and adherent human embryonic
stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis. Journal of Biomedical Science, 13(3): 433-45(2006).
 
7. Boon-Chin, Boon, Hua LIU, Zigang GE, Tong CAO. Mechanical dissociation of human embryonic stem cell colonies by manual scraping after collagenase treatment is much more detrimental to cellular viability compared to trypsinization with gentle pipetting. Biotechnology and Applied Biochemistry, 47(1):33-37(2007).
 
6. Haifeng Liu, Zigang GE, Yue Wang, Toh-Siew Lok, Vallaya Sutthikhum, James C.H. Goh. Modification of sericin-free silk fibersfor ligament tissue engineering application. Journal of Biomedical Material Research,82B (1):129-138(2007).
 
5. Boon-Chin Heng, Hua Liu, Zigang Ge, Tong Cao. Mechanical dissociation of human embryonic stem cell colonies by manual scraping after collagenase treatment is much more detrimental to cellular viability compared to trypsinization with gentle  pipetting. Biotechnol.Appl.Biochem. 47(1):33-37(2007).
 
4. Zhuo Wang, James Goh, Shamal Das De, Zigang Ge, Hongwei Ouyang, Eng Hin Lee. Efficacy of Bone Marrow Derived Stem Cells in Strengthening Osteoporotic Bone in a Rabbit Model. Tissue Engineering, 12(7): 1753-1761 (2006).
 
3. Xinxin Shao, James Goh, Dietmar Hutmacher, , Eng Hin Lee, Zigang Ge. Polymeric poly-c-caprolactone scaffolds and mesenchymal stem cells for regeneration of osteochondrol defects. Tissue Engineering, 12(6):1539-1551(2006).
 
2. Boon-Chin Heng, Chao-Peng Ye, Hua Liu, Wei-Seong Toh, Abdul-Jalil Rufaihah, Zheng Yang, Boon-Huat Bay, Zigang Ge, Hong-Wei Ouyang, Eng Hin Lee and Tong Cao. Loss of viability during freeze–thaw of intact and adherent human embryonic stem cells with conventional slow-cooling protocols is predominantly due to apoptosis rather than cellular necrosis. Journal ofBiomedical Science, 23:1-13 (2005).
 
1. 闫桂森, 史颖奇, 葛子钢. 肩锁关节损伤8例报道和文献综述. 中华骨科杂志,18(10):633-4 (1998)。
 
Update at Dec 2010