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Professor Changhui Li's group developed a novel ocular imaging system

Author:PX Post date:2014-04-23 Hits:

Recently, a novel ocular imaging system was developed by Prof. Changhui Li's research group in College of Engineering (COE), Peking University. They successfully used this system to acquire high resolution dual modality murine ocular imaging in vivo. The research paper was published in Optics Letters entitled “High-resolution dual-modality photoacoustic ocular imaging”. The corresponding author is Prof. Changhui Li. The first author is Ning Wu, a PhD student in COE, Peking University. (N. Wu, S. Ye, Q. Ren, and C. Li. http://www.opticsinfobase.org/ol/fulltext.cfm?uri=ol-39-8-2451&id=282971).

  With changes in living environment and lifestyle, various ophthalmic diseases have come to have a serious impact on human health. Glaucoma, age-related macular degeneration and diabetic retinopathy are the major cause of blindness according to the World Health Organization. Traditional optical and ultrasound ocular imaging system can provide high resolution structural imaging, while they have low contrast when imaging of vasculature and retinal pigment layer (RPE). Previous studies already proved that the structure and function of the ocular vasculature and RPE are closely related to these major diseases. Therefore, it is desired to have a system to provide high resolution, contrast and label-free imaging of ocular vasculature and RPE.

  Photoacoustic tomography (PAT) is a novel imaging method that can provide high resolution and contrast for optical absorbing tissues, such as the blood vessels. After two years’ study and experiment, Prof. Changhui Li’s group successfully developed a PAT/Ultrasound dual-modality ocular imaging system (PAOI). For the first time, they acquired high resolution iris and fundus 3D imaging of a mouse in vivo, as well as the accurate spatial co-registration (as seen in following figure). This novel system has a great potential for the ophthalmology study and clinical applications. Next, Prof. Li’s group will focus on functional ocular functional imaging, which is essential for early diagnosis of ophthalmic diseases.

   Prof. Li's group (http://bme.pku.edu.cn/otlab) is devoted to the development and implementation of novel biomedical optical imaging methods. Their major research fields include: photoacoustic tomography, fluorescence molecular tomography, and multimodal molecular imaging.